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The effect of splenectomy on fibrosarcoma “metastases” in lungs of mice

✍ Scribed by Luka Milas; Hamza Mujagic

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
372 KB
Volume
11
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Cells of a methylcholanthrene‐induced fibrosarcoma, injected intravenously into syngeneic C57Bl mice, generated tumour nodules (“metastases”) in the lungs. The number of tumour nodules was reduced in recipients whose spleens had been previously removed. This effect of splenectomy was specific (thymectomy did not affect the number of pulmonary metastases), and was greater if fewer tumour cells were injected. It was also observed that active immunization against the fibrosarcoma caused stronger inhibition of pulmonary metastases in splenectomized than in sham‐operated mice.

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