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The effect of spironolactone pretreatment on the biliary excretion and renal accumulation of inorganic mercury in the rat

✍ Scribed by Kitani Kenichi; Miura Reiko; Kanai Setsuko; Morita Yoshiko


Book ID
115773644
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
192 KB
Volume
26
Category
Article
ISSN
0006-2952

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The influence of Unithiol and Spironolac
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Rats with cannulated bile ducts were intravenously given 203HgCl2 in the dose of 120 microgram of Hg2+ per rat. Intramuscular administration of Unithiol (sodium 2,3-dimercaptopropanosulphonate) 4 and 7 h after 203Hg injection markedly increased both biliary and urinary excretion of 203Hg. In rats wi