The effect of some hallucinogenic and other drugs on the temperature of reserpinized mice

✍ Scribed by B. E. Leonard; P. D. Stonier

• Publisher: Springer
• Year: 1971
• Tongue: English
• Weight: 396 KB
• Volume: 22
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00403620

✦ Synopsis

Seven hallucinogenic and 9 centrally acting non-hallucinogenic drugs were studied for their calorigenic effects on reserpine pre-treated mice. With the exception of "Ditran" and mescaline, all the hallucinogens had a significant calorigenie effect. Of the other drugs studied, methylamphetamine and amphetamine, dimethoxyphenylethylamine, desmethylimipramine, amitryptyline and chlorpromizine also had a marked calorigenic action. Both cr and its active metabolite metaraminol, had a significant calorigenic action in reserpinized mice even though they did not significantly affect the body temperature of otherwise untreated animals. The calorigenic effect of cr was significantly antagonized by phencyclidine, ketamine, LSD and mescaline; the other hallucinogens (harmine, "Ditran" and p-bromethylamphetamine) were without effect. Of the other drugs tested, only propranolol, desmethylimipramine and amitriptyline significantly antagonized the calorigenic effect of ~-methyl-m-tyrosine in reserpinized mice. The possible mechanism of action of the drugs studied is tentatively discussed.