The effect of some drugs on the survival of guinea-pigs in cold
β Scribed by P. Huttunen; J. Hirvonen
- Publisher
- Elsevier Science
- Year
- 1976
- Weight
- 87 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0300-9432
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The effect of itraconazole (ITZ) on the pharmacokinetics of digoxin (DGX) was investigated in guinea pigs. The plasma concentrations of DGX in guinea pigs following treatment with ITZ (20 mg/kg intraperitoneally (i.p.)) after intravenous (i.v.) administration of DGX (0.125 mg/kg) were significantly
Following i.v. injection of digoxin (1Opg kg-') the ratio between digoxin concentrations in the lumen ofjejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearily with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In qu