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The effect of sodium benzoate on ammonia toxicity in rats

✍ Scribed by Sibusisiwe M. Maswoswe; Douglas M. Cyr; Ann D. Griffith; George C. Tremblay

Book ID
115759351
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
303 KB
Volume
138
Category
Article
ISSN
0006-291X

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✍ J. E. O'Connor; M. Costell; S. GrisolΓ­a πŸ“‚ Article πŸ“… 1989 πŸ› Springer 🌐 English βš– 273 KB

Sodium benzoate has been recommended for the treatment of hyperammonaemia in humans. However, benzoate potentiates ammonia toxicity and reduces urea synthesis in vitro and in vivo by decreasing the intramitochondrial levels of N-acetyl glutamate. Pretreatment of mice with carbamyl glutamate, a struc