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The potentiation of ammonia toxicity by sodium benzoate is prevented by L-carnitine

✍ Scribed by J.E. O'Connor; M. Costell; S. Grisolía

Book ID
115760632
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
447 KB
Volume
145
Category
Article
ISSN
0006-291X

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Carbamyl glutamate prevents the potentia
Carbamyl glutamate prevents the potentiation of ammonia toxicity by sodium benzoate
✍ J. E. O'Connor; M. Costell; S. Grisolía 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 273 KB

Sodium benzoate has been recommended for the treatment of hyperammonaemia in humans. However, benzoate potentiates ammonia toxicity and reduces urea synthesis in vitro and in vivo by decreasing the intramitochondrial levels of N-acetyl glutamate. Pretreatment of mice with carbamyl glutamate, a struc