The effect of SCH 23390 against toxic doses of cocaine, d-amphetamine and methamphetamine
โ Scribed by Robert W. Derlet; Timothy E. Albertson; Pam Rice
- Book ID
- 118344531
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 371 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0024-3205
No coin nor oath required. For personal study only.
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This study examined the effects of both systemic and intraaccumbens administration of SCH-23390 in rats on dopamine D1 receptor occupancy and on locomotor activity produced by intraaccumbens infusion of cocaine. In experiment 1, rats received SCH-23390 (0-1 mg/kg, IP) 15 minutes prior to intraaccumb
To investigate the role of D, dopamine receptors in the discriminative stimulus effects of cocaine, two rhesus monkeys were trained in a two-lever, food-reinforced, drug discrimination paradigm to discriminate cocaine (0.2 rag/ kg, IM) from saline. Administration of various doses of cocaine resulted