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The effect of saturation with Zn2+and other metal ions on the antibacterial activity of ovotransferrin

โœ Scribed by P. Valenti; P. Visca; G. Antonini; N. Orsi; E. Antonini

Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
416 KB
Volume
176
Category
Article
ISSN
0300-8584

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โœฆ Synopsis

The antibacterial activity of metal complexes of ovotransferrin was tested "in vitro" against different bacterial species and the Zn2+ saturated ovotransferrin appeared to be the most active by comparison with the apo-protein and other metal complexes. Appropriate controls showed that such an effect was neither due to Zn2+ ions, nor to iron deprivation, but to a specific activity of the Zn-ovotransferrin complex. This antibacterial activity required a direct contact of Zn-ovotransferrin with the bacterial surface. In vivo experiments confirmed the higher antibacterial activity of Zn-ovotransferrin as compared with the apo-form.

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