The effect of RO15-1788 on cardiovascular depression caused by fentanyl and diazepam
โ Scribed by Takeshi Sone; Toshimasa Kato; Ikuo Tsukahara; Tomokazu Harada; Michio Yamamoto; Alan Talbot
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 762 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0913-8668
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In this study we examined the effects of lorazepam (2.0 mg PO) plus either placebo or one of three doses of the benzodiazepine antagonist Ro 15-1788 (0.3 mg, 1.0 mg or 3.0 mg IV) on measures of memory, attention and sedation. We found that lorazepam impaired verbal secondary memory performance, but
After 3 days of dosing rats with lorazepam (0.25 mg/kg), tolerance developed to its sedative effects. Recovery from this tolerance was rapid. No differences could be detected in undrugged behaviour 24 h after the last dose and no differences in response to a probe injection could be found when 2 dru