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The effect of repeated electroconvulsive shocks on growth hormone secretion and growth hormone responses to clonidine in the intact rat

✍ Scribed by J. A. Steiner; G. Evans; D. G. Grahame-Smith

Publisher: Springer
Year: 1982
Tongue: English
Weight: 289 KB
Volume: 76
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00430767

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✦ Synopsis

The effect of repeated electroconvulsive shocks (ECS) on growth hormone (GH) secretion was studied in rats. Male Sprague-Dawley animals were given one ECS daily for 10 days under halothane anaesthesia. Control animals were anaesthetised only. GH secretion was studied 24 h after the last ECS or sham procedure. Background GH secretion was significantly greater in ECS-treated than in sham-treated animals (P< 0.001). The GH response to IV clonidine (0.01 -0.1 mg/kg) did not differ between the two groups. The size of the GH response was not directly related to the basal GH secretion and could not be explained in terms of it.

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