The effect of recombinant BPI21 on endotoxin-induced mortality in rats with bile duct ligation
β Scribed by A.N. Kimmings; S.J.H. van Deventer; H. Obertop; D.J. Gouma
- Book ID
- 116121464
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 263 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0300-2977
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In an earlier study we showed that bile duct-ligated rats were highly susceptible to gentamicin nephrotoxicity and that oral calcium administration had a pronounced protective effect. The mechanism by which this occurs is unclear. Because cations compete with gentamicin for tubule binding sites, it