The effect of probenecid on the renal elimination of cimetidine
โ Scribed by Gisclon, Lee G; Boyd, Rebecca A; Williams, Roger L; Giacomini, Kathleen M
- Book ID
- 109844665
- Publisher
- Nature Publishing Group
- Year
- 1989
- Tongue
- English
- Weight
- 763 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0009-9236
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
In a randomized, double-blind, cross-over experiment, 6 healthy consenting male subjects were administered cimetidine 600 mg or ranitidine 300 mg or placebo p.o. q12h x 2 days. Nicotine bitartrate was administered i.v. on day 2 (1 microgram/kg/min) x 30 min. After cimetidine mean nicotine total and
Both cimetidine therapy and cirrhosis individually interfere with normal elimination of various drugs. Cimetidine is often prescribed in patients with cirrhosis but there is incomplete data on its effect on drug elimination in cirrhotics. The purpose of this study was to address this issue. Eight st