The effect of prenatal treatment with steroids and preterm delivery in a model of myelomeningocele on the rabbit foetus
✍ Scribed by César G. Fontecha; Jose L. Peiró; Marius Aguirre; Francesc Soldado; Patricia Paz; Marc Oria; Núria Torán; Vicenç Martinez-Ibáñez
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 242 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0179-0358
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## Abstract ## Objective To investigate the effects of combination treatment with an anticoagulant (warfarin) plus a lipid‐lowering agent (probucol) on the prevention of steroid‐induced osteonecrosis (ON) in rabbits. ## Methods Adult male Japanese white rabbits were injected once intramuscularly
Background Several groups including our own have reported gene delivery to fetal organs by vector administration into the amniotic cavity. Based on these studies we hypothesised that the large surface of the fetal skin may be exploitable for high level production of systemically required gene produc