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Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model

✍ Scribed by Kentaro Iwakiri; Yutaka Oda; Yasunori Kaneshiro; Hiroyoshi Iwaki; Toshiaki Masada; Akio Kobayashi; Akira Asada; Kunio Takaoka

Publisher
Springer Japan
Year
2008
Tongue
English
Weight
226 KB
Volume
13
Category
Article
ISSN
0949-2658

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Combined effects of an anticoagulant and
Combined effects of an anticoagulant and a lipid-lowering agent on the prevention of steroid-induced osteonecrosis in rabbits
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## Abstract ## Objective To investigate the effects of combination treatment with an anticoagulant (warfarin) plus a lipid‐lowering agent (probucol) on the prevention of steroid‐induced osteonecrosis (ON) in rabbits. ## Methods Adult male Japanese white rabbits were injected once intramuscularly