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The Effect of Polyethylene Glycol 400 on Gastrointestinal Transit: Implications for the Formulation of Poorly-Water Soluble Drugs

✍ Scribed by Abdul W. Basit; J. Michael Newton; Michael D. Short; Wendy A. Waddington; Peter J. Ell; Larry F. Lacey


Book ID
110295690
Publisher
Springer US
Year
2001
Tongue
English
Weight
82 KB
Volume
18
Category
Article
ISSN
0724-8741

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A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH < 4),