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Effect of hydrotalcite-like compounds on the aqueous solubility of some poorly water-soluble drugs

✍ Scribed by Valeria Ambrogi; Giuseppe Fardella; Giuliano Grandolini; Morena Nocchetti; Luana Perioli

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
221 KB
Volume
92
Category
Article
ISSN
0022-3549

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✦ Synopsis

A new approach of improving drug dissolution properties is described. This method exploits the property of a carrier owing to the hydrotalcite-type anionic clays (HTlc). HTlc is an inorganic layered solid that lodges anionic compounds among its layers. As HTlc dissolves at acidic pH values (pH < 4), the anions intercalated among the layers are promptly released in the medium. In this article some nonsteroidal antiinflammatory drugs were chosen as models of poorly water-soluble drugs. They were intercalated in HTlc and solubility measurements in acidic medium were performed. A remarkable improvement of drug solubility was observed especially in the case of indomethacin.

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