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The effect of physiological levels of divalent metal ions on the interaction of daunomycin with DNA: evidence of a ternary daunomycin-Cu2+-DNA complex

โœ Scribed by Don R. Phillips; Gayle A. Carlyle

Book ID
115775647
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
430 KB
Volume
30
Category
Article
ISSN
0006-2952

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๐Ÿ“œ SIMILAR VOLUMES

Studies on nucleic acids. VIII. Changes
Studies on nucleic acids. VIII. Changes in the stability of DNA secondary structure by interaction with divalent metal ions
โœ H. Venner; Ch. Zimmer ๐Ÿ“‚ Article ๐Ÿ“… 1966 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 828 KB

The melting temperature of a natural DNA is decreased in the presence of increasing amounts of copper ions, whereas other divalent metal ions stabilize the DNA secondary structure a t low ionic strength. At 1.28 X lO-4M, Cuz+ produces a decrease of T,,, depending on base composition. At very low Cu\