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The Effect of Organotin Compounds on the Permeability of Model Biological Membranes

✍ Scribed by William R. Cullen; F. Geoffrey Herring; Basil U. Nwata

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 247 KB
Volume: 11
Category: Article
ISSN: 0268-2605
DOI: 10.1002/(sici)1099-0739(199705)11:5<369::aid-aoc585>3.0.co;2-o

No coin nor oath required. For personal study only.

✦ Synopsis

The efflux of dimethylarsinic acid (DMA) from liposomes formed from egg phosphatidylcholine (EPC) is increased when tributyltin chloride (TBT) is added to the extraliposomal compartment; however the addition of monobutyltin trichloride (MBT) slows down the efflux. When the liposomes are prepared from EPC and organotin compounds, different mechanisms for DMA efflux seem to operate: TBT-EPC liposomes show a mixture of facilitated and passive diffusion; MBT-EPC liposomes show only passive diffusion. The facilitated diffusion of DMA Ϫ seems to be stopped by the addition of TBT to the extraliposomal compartment.

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