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The Effect of Non-Coordinated Water in the Heme Pocket on the Ligand Binding Dynamics of Heme Proteins

✍ Scribed by Nguyen, Rosa L.; Lintner, Benjamin W.; Pena, Ignacio L.; Tipgunlakant, Pooncharas; Soman, Jayashree; Birukou, Ivan; Olson, John S.; Asarnow, Daniel E.; Kliger, David S.; Goldbeck, Robert A.; Esquerra, Raymond M.

Book ID
122139330
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
62 KB
Volume
98
Category
Article
ISSN
0006-3495

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The kinetics of ligand binding to heme proteins studied by flash photolysis display an algebraic time dependence at low temperatures in contrast exponential recombination observed under physiological conditions. This result shows that protein structures should be viewed as a tune average of intercon