The effect of N-methylation on fenfluramine's neurotoxic and pharmacologic actions
โ Scribed by Jennifer Fasciano; Thomas Steele; Neal Castagnoli; Jonathan Katz; George Ricaurte
- Book ID
- 114002493
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 173 KB
- Volume
- 763
- Category
- Article
- ISSN
- 0006-8993
No coin nor oath required. For personal study only.
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Until recently, (ฯฎ)fenfluramine (FEN) was widely prescribed as an appetite suppressant. In animals, FEN is a potent and selective brain serotonin neurotoxin. The present studies assessed the effects of phentermine (PHEN), an appetite suppressant frequently used clinically in combination with FEN, on
In N-methyl amino acids, the hydrogen of the N-H group is replaced with a bulky methyl group. While this change is expected to destabilize helical structures, the amount of destabilization is not known. Here the N-methyl group is placed into several positions of the helical peptides, acetyl-WGG( EAA