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The effect of myotonic dystrophy transcript levels and location on muscle differentiation

โœ Scribed by Nikolaos P. Mastroyiannopoulos; Elina Chrysanthou; Tassos C. Kyriakides; James B. Uney; Mani S. Mahadevan; Leonidas A. Phylactou


Book ID
116297589
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
522 KB
Volume
377
Category
Article
ISSN
0006-291X

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## Abstract Myotonic muscular dystrophy (DM) is characterized by abnormal skeletal muscle Na channel gating and reduced levels of myotonic dystrophy protein kinase (DMPK). Electrophysiological measurements show that mice deficient in __Dmpk__ have reduced Na currents in muscle. We now find that the