Effect of testosterone on muscle protein synthesis in myotonic dystrophy
β Scribed by Dr Robert C. Griggs; David Halliday; William Kingston; Richard T. Moxley III
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 720 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
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## Abstract Myotonic muscular dystrophy (DM) is characterized by abnormal skeletal muscle Na channel gating and reduced levels of myotonic dystrophy protein kinase (DMPK). Electrophysiological measurements show that mice deficient in __Dmpk__ have reduced Na currents in muscle. We now find that the
## Abstract The influence of the membraneβstablizing agents diphenylhydantoin (DPH) and orgotein (a drug with superoxide dismutase activity) on protein synthesis was studied in cultured human muscle cells obtained from 7 patients with Duchenne muscular dystrophy (DMD) and 14 controls. The cultures