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The effect of multiple rising doses of Ro 11-2465 (serotonin uptake inhibitor) on serotonin content of human platelets

✍ Scribed by T. Lenehan; L. M. O. Omer; M. Kenny; R. Lambe; A. Darragh

Publisher: Springer
Year: 1981
Tongue: English
Weight: 241 KB
Volume: 74
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00431746

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✦ Synopsis

Ro 11-2465, a cyanide derivative of imipramine with serotonin uptake inhibitory properties, was investigated in six healthy volunteers for its effect on serotonin concentration in blood platelets. The initial dose was 1 mg daily, the maximum dose of 3rag being reached on day 3 and maintained for 7 days.

A significant decrease in the platelet serotonin concentration was not observed until 3 days after the start of drug administration, after which depletion was rapid. After 5 days of treatment, the reduction was about 80 % compared to predrug level. Serotonin restoration after drug withdrawal was very slow, and 5 days after discontinuation, it was still 70 % below its baseline level.

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