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Effects of tranylcypromine on serotonin content and monoamine oxidase activitity of the human blood platelet

✍ Scribed by Gregory F. Oxenkrug; Richard Balon; Roy B. McCauley; Iain M. McIntyre

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 256 KB
Volume: 5
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.470050208

No coin nor oath required. For personal study only.

✦ Synopsis

Inhibition (>80 per cent) of platelet monoamine oxidase (MAO-B type) and an increase of platelet serotonin content were observed after tranylcypromine administration. It is suggested that the increase in platelet serotonin reflects MAO-A inhibition, which may be correlated with antidepressant and hypotensive effects of M A 0 inhibitors.

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