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The effect of lithium on thyroid iodine release in patients with primary affective disorder

✍ Scribed by Harold E. Carlson; Jacob Robbins; Dennis L. Murphy

Publisher
Springer
Year
1974
Tongue
English
Weight
376 KB
Volume
35
Category
Article
ISSN
0033-3158

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✦ Synopsis

Thyroid iodine release measured by the double isotope method of Nicoloff was studied in patients with manic-depressive illness before, during and after treatment with lithium carbonate. The urinary lZSI/ZalI isotope ratio was measured following administration of Nal~SI and z3~I-thyroxine. In three of four subjects, lithium caused a transient decrease in diurnal variation and a temporary reduction in the normal increase of the 1~5I/~3zI ratio during the first week of therapy or after alithium dose increase. In addition, in two of three subjects, a rebound increase in the isotope ratio occurred following cessation of lithium administration. These changes most likely represent a direct inhibitory effect of lithium on the thyroid iodine release process.

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