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Preliminary observations on the use of corynebacterium parvum in patients with primary intracranial tumors: Effect on intracranial pressure

โœ Scribed by Robert G. Selker; Norman Wolmark; Bernard Fisher; Pearl Moore

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
279 KB
Volume
10
Category
Article
ISSN
0022-4790

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โœฆ Synopsis

It has been observed that patients with metastatic brain lesions developed neurologic symptoms when given Corynebacterium parvum. To obtain more information in patients with intracranial mass lesions, intracranial pressures (ICP) were measured or observed in six patients undergoing C. parvum therapy.

All patients except two (one previously shunted, one recently operated) demonstrated a profound increase in ICP. It is presumed that either edema is formed within brain and tumor tissue (inasmuch as neurologic deterioration has not been observed in patients without an intracranial lesion) or transient increases in cerebral blood flow adversely alter an already compromised intracranial volume. Surgical decompression of tumor volume or use of Lasix@ may abort this response to C . parvum infusion.

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