𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effect of large doses of dexamethasone on the cerebrospinal fluid pressure in patients with supratentorial tumors

✍ Scribed by E. Alberti; A. Hartmann; H. -J. Schütz; F. Schreckenberger

Publisher
Springer
Year
1978
Tongue
English
Weight
894 KB
Volume
217
Category
Article
ISSN
0340-5354

No coin nor oath required. For personal study only.

✦ Synopsis

The effect of large doses of dexamethasone (80 mg) on the cerebrospinal fluid pressure (CSFP) was investigated with continuous lumbar CSFP measurement over 24 h in 10 patients with supratentorial cerebral tumors and clinical signs of elevated intracranial pressure. There was a further slight rise in CSFP with an unchanged pressure pattern in the course of observation of the untreated control group. A marked lowering of CSFP was observed within 6 h after initial intravenous administration of dexamethasone to seven of the treated patients. In four of the treated patients an unequivocal and in five only a moderate CSFP lowering was measured at the end of the registration. One patient had a slight rise in pressure. The plateau waves of all the patients treated decreased in height, frequency and duration within the first hours, while fluctuations in pressure level and CSFP amplitude were reduced.

📜 SIMILAR VOLUMES

Increased polyamine concentrations in th
Increased polyamine concentrations in the cerebrospinal fluid of patients with brain tumors
✍ Laurence J. Marton; Olle Heby; Charles B. Wilson 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 290 KB 👁 1 views

## Abstract An automated method for the quantitative analysis of the polyamines putrescine, spermidine and spermine in cerebrospinal fluid (CSF) was used to analyze CSF samples from 37 patients with central nervous system (CNS) tumors and from 13p atients without tumors. The putrescine and spermidi

The effect ofl-tryptophan administration
The effect ofl-tryptophan administration on the concentration of probenecid in plasma and cerebrospinal fluid in patients
✍ David L. Dunner; Sofia Heiber; James M. Perel 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 327 KB

The administration of large doses of probenecid has been used to study the central nervous system metabolism of catecholamines and indoleamines in patients with affective disease. It has been reported that alterations of the binding of L-tryptophan to plasma albumin binding sites occur during proben

On the nature of endogenous antiexcitato
On the nature of endogenous antiexcitatory factors in the cerebrospinal fluid of patients with demyelinating neurological disease
✍ Heinrich Brinkmeier; Markus J. Seewald; Kurt H. Wollinsky; Reinhardt Rüdel 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 840 KB

The cerebrospinal fluid (CSF) of patients with demyelinating neurological disease, such as Guillain-Barre syndrome or multiple sclerosis, contains factors that inhibit the excitatory Na+ current. Such antiexcitatory factors are occasionally also detectable in CSF from patients with other neurologica