Measurements were made in CCI, of the formation constant K,, of the 1 : l hydrogen-bonded complexes between the reference donor 4-fluorophenol and the intramolecular hydrogen-bonded systems I (one lone pair on heteroatom Y, one intramolecular hydrogen bond: 8-hydroxyquinaldine and 2-(2-hydroxyphenyl
The effect of intramolecular bydrophobic bonding on partition coefficients
โ Scribed by Hansch, Corwin; Anderson, Susan M.
- Book ID
- 126013616
- Publisher
- American Chemical Society
- Year
- 1967
- Tongue
- English
- Weight
- 542 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
The intramolecular hydrogen bonding (chelation) of salicylaldehyde, methyl salicylate, N , Ndimethylsalicylamide and 2-hydroxyacetophenone was studied by IR spectroscopy in different phases used for partition coefficient determinations. The extent of chelation was found to be highly sensitive to the
Precise partition coefficients in 1-octanol-water at 25 degrees C were determined for three 2-thiobarbituric acids and 14 barbituric acids with a wider range of substituents. The experimental log P values (log Pexp) of barbituric acids were correlated with the carbon number and the branching effect