The kidney plays a pivotal role in the clearance and degradation of circulating insulin and is also an important site of insulin action. The kidney clears insulin via two distinct routes. The first route entails glomerular filtration and subsequent luminal reabsorption of insulin by proximal tubular
The effect of insulin on renal sodium metabolism
β Scribed by R. A. DeFronzo
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 776 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0012-186X
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π SIMILAR VOLUMES
## OPU' E FIGURE It was shown by Krebs and Eggleston ( '38) using a pigeon muscle mince in the presence of boiled muscle extract and various intermediates of the citric acid cycle, that insulin could effect a n increase in oxygen uptake. This work was subsequently confirmed by other workers (Shorr
The sodium retaining effect of insulin was studied in ten Type 2 (non-insulin-dependent) diabetic patients (mean age 56 (43-73)years, mean body mass index 29.5 (24.2-33.7) kg/m o and eight age-matched control subjects (mean age 57 (43~58)years, mean body mass index 23.4 (20.8-26.6) kg/m2). The renal