An insulin effect on sponge metabolism
โ Scribed by Gordon, Edwin E. ;Spiegel, Melvin ;Villee, Claude A.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1955
- Tongue
- English
- Weight
- 240 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0095-9898
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โฆ Synopsis
OPU' E FIGURE
It was shown by Krebs and Eggleston ( '38) using a pigeon muscle mince in the presence of boiled muscle extract and various intermediates of the citric acid cycle, that insulin could effect a n increase in oxygen uptake. This work was subsequently confirmed by other workers (Shorr and Barker, '39; Stadie et. al., '40; Stare and Baumann, '40). W e have been able t o demonstrate this action of insulin on a n invertebrate -the sponge, Microciona prolifera.
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Insulin resistance is a significant pathogenetic factor in the development of non-insulin-dependent diabetes mellitus (NIDDM). A new class of drugs, the thiazolidinediones, have been shown to lower blood glucose levels without stimulating insulin secretion. We report the metabolic effect of the thia