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The effect of inorganic phosphate on the production of avermectin in Streptomyces avermitilis

✍ Scribed by Eva Čurdová; Vendulka Jechová; Jiří Zima; Zdenko Vaněk

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
370 KB
Volume
29
Category
Article
ISSN
0233-111X

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✦ Synopsis

The effect of phosphate on the production of avermectin Bla, growth and utilization of glucose in the course of cultivation of Streptomyces avermitilis on a complex and chemically defined medium has been studied. Phosphate added at the beginning of cultivation at 1-20 mmol/l did not distinctly affect the production of secondary metabolite. From the results it follows that the biosynthesis of avermectin tolerates high concentrations of phosphate in the medium.

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✍ Abdeltif Amrane 📂 Article 📅 2000 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 106 KB 👁 1 views

For batch culture of lactic acid bacteria, seed cultures have to be highly supplemented with complex substrates to obtain an active inoculum. In contrast, for industrial applications, nitrogen supplementation of the fermenter culture must be kept low to minimize costs. Addition of inorganic phosphat