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The Effect of Hypoxia on Mechanical Stretch-Activated Hypertrophic Gene Expression in Neonatal Mouse Ventricular Cardiomyocytes

โœ Scribed by Nogal, Nekeisha S.; Holt, Kelly C.; Hsia, Allison; Omens, Jeffrey H.; McCulloch, Andrew D.


Book ID
122591850
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
40 KB
Volume
102
Category
Article
ISSN
0006-3495

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It is generally accepted that mechanical stress of cardiomyocytes increases RNA and protein synthesis of myosin heavy chain (MHC) quantitatively but it is still a matter of debate whether MHC gene expression is also changed qualitatively. We investigated expression of MHC genes of spontaneously cont