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The effect of hypothermic ischemia on the α-adrenergic mechanisms of the canine tibia vascular bed

✍ Scribed by T. R. C. Davis; M. B. Wood; P. M. Vanhoutte

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
550 KB
Volume
10
Category
Article
ISSN
0736-0266

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✦ Synopsis

Abstract

The effect of hypothermic ischemia on α‐1 and ‐2 adrenergic receptor mediated vasoconstriction has been studied in an in vitro perfused canine tibia preparation. Bones were perfused at a constant rate with aerated (95% O~2~, 5% CO~2~) modified Krebs Ringer solution and the effect of bolus injections of norepinephrine (0.025–6.4 nmol) on the perfusion pressure was studied. For all bones the first dose‐response curve was produced under control conditions. In one group the second dose‐response curve was generated during a constant infusion of prazosin (α‐1 adrenergic antagonist); in another it was produced during a constant infusion of rauwolscine (α‐2 adrenergic antagonist); in the control group it was generated under control conditions. The results demonstrate that, after 48 h of hypothermic ischemia, α‐1 adrenergic‐mediated vasoconstriction was significantly attenuated (p < 0.001). However, α‐2 adrenergic‐mediated vasoconstriction was unaffected by increasing periods of hypothermic ischemia.

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