✦ LIBER ✦

Effect of human adrenomedullin on vascular resistance of the canine tibia

✍ Scribed by Teiji Kato; Allen T. Bishop; Michael B. Wood; Mary L. Adams

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 443 KB
Volume: 14
Category: Article
ISSN: 0736-0266
DOI: 10.1002/jor.1100140224

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An ex vivo model of a perfused canine tibia was used to investigate the effect of human adrenomedullin, a novel peptide with known vasodilator properties, on the vascular resistance of bone. Human adrenomedullin has a potent and long‐lasting vasodilator effect in the canine tibia following precontraction of vascular smooth muscle by infusion of prostaglandin F~2α~. A 0.1 ml bolus injection of 10^−5^ M human adrenomedullin suppressed the pressor response of the canine tibia preparation to an infusion of norepinephrine by 43–52% for a duration of 100 minutes. An injection of 10^−6^ adrenomedullin suppressed the pressor response to an infusion of norepinephrine by 22–23% for a duration of 40 minutes. These data suggest that human adrenomedullin may be a potent and long‐acting vascular smooth‐muscle relaxant in bone.

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