✦ LIBER ✦

The effect of hyperglycaemia on the absorption of glibenclamide in patients with non-insulin-dependent diabetes mellitus

✍ Scribed by A. Hoffman; Y. Fischer; D. Gilhar; I. Raz

Publisher: Springer
Year: 1994
Tongue: English
Weight: 269 KB
Volume: 47
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00193478

No coin nor oath required. For personal study only.

✦ Synopsis

We have studied the absorption of glibenclamide 10 mg as a single morning dose in 7 patients with non-insulin-dependent diabetes mellitus, comparing normoglycaemic and hyperglycaemic states. The maximal glibenclamide plasma concentrations were significantly higher in the normoglycaemic than in the hyperglycaemic state (448 vs 228 mg.l-1) and these peak concentrations were attained faster in normoglycaemia than in hyperglycaemia (3.7 vs 5 h). We conclude that the absorption of glibenclamide in the two states is different.

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