✦ LIBER ✦

The effect of histamine on the growth of cultured fibroblasts isolated from normal and keloid tissue

✍ Scribed by James D. Russell; Shirley B. Russell; Kathryn M. Trupin

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 483 KB
Volume: 93
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040930310

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cultured fibroblasts derived from human keloid tissue are presented as a possible model system for studying the genetic regulation of cell growth. Histamine is shown to have a marked effect on the growth of cultured fibroblasts. A small increase in growth rate is seen during the log phase of the culture cycle and a 50% increase in cell number is observed during the plateau phase. Differences in the extent of growth stimulation are observed between strains isolated from different individuals. While most strains showed approximately 50% stimulation, a few were not stimulated and some strains gave a 100% or greater increase in cell number due to histamine. This phenotypic difference in extent of growth stimulation in response to histamine cannot be attributed to the gene or genes for keloid formation. However, elevated levels of histamine in vivo may be a contributing factor to the abnormal cell growth observed in this disorder. The extent of growth stimulation due to histamine decreases with repeated subculturing.

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