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The effect of hematoporphyrin and light on human platelets. III. Release of potassium and acid phosphatase

✍ Scribed by Philip D. Zieve; Harvey M. Solomon

Publisher
John Wiley and Sons
Year
1966
Tongue
English
Weight
177 KB
Volume
68
Category
Article
ISSN
0021-9541

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✦ Synopsis

Human platelets, exposed to hematoporphyrin and light, were depleted of potassium and acid phosphatase. A linear relationship was demonstrated between the per cent depletion of potassium from irradiated platelets and the log dose of hematoporphyrin. The initial release of potassium and acid phosphatase from irradiated platelets was first order. Rate constants demonstrated that potassium was released five times faster than acid phosphatase. At (4^{\circ} \mathrm{C}), release of both potassium and acid phosphatase was the same as at (37^{\circ} \mathrm{C}). These results are compared to previous data on the release of serotonin from irradiated platelets.

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