The effect of food or milk on the absorption kinetics of ofloxacin

✍ Scribed by M. N. Dudley; C. R. Marchbanks; S. C. Flor; B. Beals

• Book ID: 104718898
• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 336 KB
• Volume: 41
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00314986

✦ Synopsis

We have studied the effects of food or milk on the absorption of ofloxacin in 21 healthy male volunteers in a three-way crossover design. Milk did not alter the rate or extent of absorption of ofloxacin or its elimination. Food altered the onset and/or rate of absorption, but not the extent of absorption or the elimination rate. Thus, food reduced peak ofloxacin concentrations (Cmax) by 20% compared with fasting conditions and the time to reach maximum concentration (tmax) was prolonged on average by 1 h. However, the extent of absorption and the half-life (t 1/2) of ofloxacin were the same after each treatment. These data indicate that food and milk have a clinically insignificant effect on ofloxacin absorption.