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The effect of food on the interaction of ofloxacin with sucralfate in healthy volunteers

✍ Scribed by J. Kawakami; H. Kotaki; T. Seino; Y. Sawada; T. Iga; T. Matsuse; Y. Fukuchi; H. Orimo

Publisher: Springer
Year: 1994
Tongue: English
Weight: 291 KB
Volume: 47
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00193481

No coin nor oath required. For personal study only.

✦ Synopsis

We have studied the effect of food on the interaction of ofloxacin with sucralfate. Six healthy men took a single oral dose of ofloxacin (200 rag) on 4 occasions: alone after overnight fasting or after breakfast (non-fasting), and with sucralfate fasting or non-fasting.

There were no significant differences in the plasma concentration-time profiles of ofloxacin after ofloxacin alone between fasting and non-fasting conditions. On the other hand, the peak plasma concentration and AUC of ofloxacin after co-administration with sucralfate while fasting fell by 70 and 61% compared with ofloxacin alone; the changes non-fasting were 39 and 31% respectively. The interaction of ofloxacin with sucralfate was markedly reduced by food, but still could not be disregarded.

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