The effect of food on oral melphalan absorption
โ Scribed by Phillip A. Reece; Dusan Kotasek; Raymond G. Morris; Barry M. Dale; Robert E. Sage
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 388 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Previous studies have demonstrated that the bioavailability of melphalan and chlorambucil may be reduced under non-fasting conditions, and that the gastrointestinal and cellular absorption of melphalan is an active process, while that of chlorambucil is passive. In view of these findings, the effect
DPC 961 is a low-solubility, high-permeability, second-generation non-nucleoside reverse transcriptase inhibitor. The purpose of these studies was to evaluate the effects of drug substance and formulation variables on DPC 961 oral absorption, and to compare fed and fasted state oral absorption. To a