The Effect of Excipients on the Molecular Mobility of Lyophilized Formulations, as Measured by Glass Transition Temperature and NMR Relaxation-Based Critical Mobility Temperature
โ Scribed by Sumie Yoshioka; Yukio Aso; Shigeo Kojima
- Book ID
- 110378968
- Publisher
- Springer US
- Year
- 1999
- Tongue
- English
- Weight
- 967 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0724-8741
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๐ SIMILAR VOLUMES
The purpose of this study was to explore why changes in the molecular mobility associated with glass transition, the timescale of which is on the order of 100 s, can be detected by measuring the nuclear magnetic resonance relaxation times that reflect molecular motions on the order of 10 kHz and 1 M
To gain further insight into the effect of molecular mobility on the crystallization rate of amorphous drugs, the mean relaxation times of amorphous nifedipine and phenobarbital were calculated based on the AdamยฑGibbsยฑVogel (AGV) equation, using the parameters D, T 0 , and T f , derived from the hea