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Glass transition-related changes in molecular mobility below glass transition temperature of freeze-dried formulations, as measured by dielectric spectroscopy and solid state nuclear magnetic resonance

โœ Scribed by Yoshioka, Sumie (author);Aso, Yukio (author)


Publisher
John Wiley and Sons Inc.
Year
2005
Tongue
English
Weight
247 KB
Volume
94
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES


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The purpose of this study was to explore why changes in the molecular mobility associated with glass transition, the timescale of which is on the order of 100 s, can be detected by measuring the nuclear magnetic resonance relaxation times that reflect molecular motions on the order of 10 kHz and 1 M

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To gain further insight into the effect of molecular mobility on the crystallization rate of amorphous drugs, the mean relaxation times of amorphous nifedipine and phenobarbital were calculated based on the AdamยฑGibbsยฑVogel (AGV) equation, using the parameters D, T 0 , and T f , derived from the hea