The effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine on DNA repair and mutagenesis of herpes simplex virus type 1
✍ Scribed by Glenn J. Bubley; Jan Balzarini; Clyde S. Crumpacker; Erik de Clercq; Lowell E. Schnipper
- Book ID
- 116075344
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 310 KB
- Volume
- 161
- Category
- Article
- ISSN
- 0042-6822
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The influence of (E)-5-(2-bromovinyl)-2'-de~xyuridine (BVDU), caffeic acid oxidation product (KOP), and trisodiumphosphonoformate (TPF) on the course of the primary cutaneous herpes simplex virus infection was investigated by means of a guinea pig test model. The antiviral substances were applied in
## Abstract With development of antiviral drugs, the need to identify a virus as to drug sensitivity becomes increasingly of importance. The compound (E)‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU) has been shown to be much more inhibitory to the replication of herpes simplex virus type 1 (HSV‐1) and v