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The effect of dopamine partial agonists on the nicotine dependency in patients with schizophrenia

✍ Scribed by Se Hee Kim; Doug Hyun Han; So Youn Joo; Kyung Joon Min

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
80 KB
Volume
25
Category
Article
ISSN
0885-6222

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✦ Synopsis

Abstract

Objective

We compared the effects of haloperidol and three atypical antipsychotics (risperidone, olanzapine, and aripiprazole) on nicotine dependence in schizophrenic patients.

Methods

One hundred and thirty nine schizophrenic patients, who began using antipsychotic medication, were assessed for severity of nicotine dependence and for cigarette craving at baseline and following 8 weeks of treatment using the Fagerström Tolerance Questionnaire (FTQ) and a Likert‐style, seven point, visual‐analogue rating scale.

Results

Nicotine dependence increased in the haloperidol group, but not in atypical antipsychotics groups. Patients treated with aripiprazole showed a reduction both in nicotine dependence and cigarette craving.

Conclusions

The effects of aripiprazole, a partial agonist of the dopamine D2 receptor, may reduce the severity of nicotine dependence in schizophrenic patients. Copyright © 2009 John Wiley & Sons, Ltd.

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