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The effect of quetiapine on aggression and hostility in patients with schizophrenia

✍ Scribed by Celso Arango; Miguel Bernardo

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
66 KB
Volume
20
Category
Article
ISSN
0885-6222

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✦ Synopsis

Abstract

A post hoc analysis of data from three placebo‐controlled, double‐blind, randomized trials was carried out to determine the efficacy of quetiapine in aggression and hostility in patients with schizophrenia. Quetiapine treatment induced statistically significantly greater improvements in BPRS positive symptom cluster scores and three measures of hostility derived from the BPRS, compared with placebo, in patients symptomatic at baseline. A path analysis showed that the improvements in hostility were highly correlated with improvements in positive symptoms and there was no consistent relationship between sedation and hostility. Aggressive behaviour appears to be related to positive symptoms of schizophrenia. Quetiapine may be a suitable option for patients with schizophrenia and aggressive behaviour. Copyright Β© 2005 John Wiley & Sons, Ltd.

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