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The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat

✍ Scribed by C.L. Van Der Wilt; A. Marinelli; H.M. Pinedo; J. Cloos; K. Smid; C.J.H. Van De Velde; G.J. Peters

Book ID
116166145
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
977 KB
Volume
31
Category
Article
ISSN
0959-8049

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Schedule dependent inhibition of thymidy
Schedule dependent inhibition of thymidylate synthase and tumor growth by 5-fluorouracil in yoshida sarcoma bearing rats
✍ Toshimasa Tsujinaka Md; Yoshihiro Kido; Hitoshi Shiozaki; Takesada Mori; Constan πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 431 KB

## Abstract Schedule dependent inhibition of thymidylate synthase (TS) and tumor growth by 5‐fluorouracil (FUra) was examined in Yoshida sarcoma (YS) bearing Donryu rats. After implantation of YS cells (1 Γ— 10^4^), FUra (20 mg/kg/day) was continuously (group C) or daily bolus injection (group B) ad