The effect of different dosing regimens of levodopa/carbidopa/entacapone on plasma levodopa concentrations
✍ Scribed by Kimmo Ingman; Tarja Naukkarinen; Mikko Vahteristo; Irja Korpela; Mikko Kuoppamäki; Juha Ellmén
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 341 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0031-6970
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## Abstract Levodopa combined with a dopa‐decarboxylase inhibitor, such as carbidopa, shifts the metabolism to the COMT pathway. Adding the peripheral acting COMT inhibitor entacapone provides improvement for patients with PD suffering from motor fluctuations. We studied the effects of the enzyme i
In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate vari