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The effect of different amine bases in the Swern oxidation of β-amino alcohols

✍ Scribed by William Chrisman; Bakthan Singaram


Book ID
104256652
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
272 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis


Swern oxidation of E-amino alcohols containing tertiary amino groups afforded the corresponding ~-amino carbonyl compounds in fair to excellent yield. Yields were dependent on the steric requirement of the amine base used for the reaction and were optimized by the use of N-methylpyrrolidine, N-ethylpiperidine, or triethylamine, depending on the ~-amino alcohol substrate.


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