The effect of ?-cyanoacrylates on wound healing

✍ Scribed by Houston, Stuart ;Hodge, John W. ;Ousterhout, Douglas K. ;Leonard, Fred

• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 408 KB
• Volume: 3
• Category: Article
• ISSN: 0021-9304
• DOI: 10.1002/jbm.820030208

✦ Synopsis

The use of cyarioacrylate tissue adhesives provides a quick met,hod of closing wounds by nonsuture techniqnes. This st,udy was undertaken to determine the relative effects on healing of a number of alkyl a-cyanoacrylate tissue adhesives compared to sutured incisions. Tissue bonds were prepared with the alkyl a-cyanoacrylate adhesives and sutrires and tested for bond st,rength in vivo in rats over periods of 1, 3, 7 , 10, and 14 days. A trend of increasing bond strength with the higher homologs was immediately apparent,. However, t,his trend was reversed a t the time of the 14 day measurements with the higher homologs of the cyanoacrylate adhesives having the lower bond strength. Microscopic examination of pulled wounds closed wit,h methyl a-cyanoacrylate showed the came to be substrate failure with the except,iori of the one hour postoperative samples which demonstrated adhesive failure. Wound failure in t,he remaining three monomers was cohesive, gradually decreasing to substrate failure a t 10 days postoperat,ive. The tensile strength of all wounds closed with tissue adhesive dropped considerably on the third day postoperative.