✦ LIBER ✦

The effect of complete carcinogens on intercellular transfer of lucifer yellow in fibroblast culture

✍ Scribed by Irene V. Budunova; Leonid A. Mittelman; Gennady A. Belitsky

Publisher: Springer
Year: 1990
Tongue: English
Weight: 855 KB
Volume: 6
Category: Article
ISSN: 0742-2091
DOI: 10.1007/bf00135026

No coin nor oath required. For personal study only.

✦ Synopsis

The effect on permeability of gap junctions of complete powerful carcinogens, 3-methylcholanthrene (MC), 7,12-dimethylbenz(a)anthracene (DMBA), ethyl methanesulfonate (EMS), and weak carcinogens, benz(a)anthracene (BA), benzo(e)pyrene (B(e)P) as well as the arylhydrorylase inhibitor 7,8-benzoflavone (7,8-BF) has been studied with the use of a dye-coupling technique and transformed Djungarian hamster DM15 fibroblasts. MC, EMS and 7,8-BF were found to exert a strong inhibitory effect on cell-to-cell dye transfer. BA and DMBA had the uncoupling activity only in 2 out of 4 experiments. B(e)P was not shown to affect LY transfer between DM15 cells. The uncoupling effect of MC, 7,8-BF and EMS (only when EMS used at the concentration of 600 /zg/ml but not 1000 #g/ml) appeared reversible. The causes of failure to detect DMBA and B(e)P effects on gap junctions are discussed.

📜 SIMILAR VOLUMES

Identification of tumor promoters by the

Identification of tumor promoters by their inhibitory effect on intercellular transfer of lucifer yellow

✍ Irene V. Budunova; Leonid A. Mittelman; Gennady A. Belitsky 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 714 KB

The effect of the tumor promoters 12-O-tetradecanoylphorbol-13acetate (TPA), mezerein, teleocidin, anthralin, the Ca2+-ionophore A23187, butylated hydroxytoluene (BHT), dichlordiphenyltrichloroethane (D D T) and phenobarbital (PB) on lucifer yellow transfer in cultures of SV-40-transformed Djungaria

Changes in the pattern of intercellular

Changes in the pattern of intercellular transfer of Lucifer yellow between villus epithelial cells during postnatal development

✍ Cheng, Hazel ;Bjerknes, Matthew 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 746 KB

The effect of radiation in combination w

The effect of radiation in combination with carcinogens on the growth of normal urothelium in explant culture

✍ C. Mothersill; A. O'Brien; C. B. Seymour 📂 Article 📅 1990 🏛 Springer-Verlag 🌐 English ⚖ 953 KB

The effect of glucose deprivation on col

The effect of glucose deprivation on collagen synthesis in fibroblast cultures

✍ Marzanna Cechowska-Pasko; Arkadiusz Surażyński; Edward Bańkowski 📂 Article 📅 2009 🏛 Springer 🌐 English ⚖ 341 KB

Desensitization of the serum effect on N

Desensitization of the serum effect on Na+ influx in cultured human fibroblasts

✍ Mitchel L. Villereal; Nancy E. Owen 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 872 KB

Stimulation of an amiloride-sensitive Na+ influx pathway, which mediates Na+/H+ exchange, has been postulated to be an important step in the initiation of DNA synthesis in quiescent human fibroblasts. If the elevation of intracellular Na+ or the alkalinization of intracellular pH resulting from the

Density-dependent effects of oxygen on t

Density-dependent effects of oxygen on the growth of mammalian fibroblasts in culture

✍ Dr. William G. Taylor; Richard F. Camalier; Katherine K. Sanford 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 776 KB

## Abstract Various concentrations of oxygen were used to determine the optimum culture medium P for survival and proliferation of attached human and mouse fibroblasts grown from different inoculum sizes. When T−15 flasks were seeded with ⪕ 2 × 10^4^ cells (⪕ 1.3 × 10^3^ cells/cm^2^), the highest p